منابع مشابه
Molecular aspects of sGC regulation
Mammalian sGC is a heterodimer composed of aand b-subunits (Figure 1) [1]. The C-terminus of each subunit contains a catalytic domain, and the active site is composed of residues from both subunits. Sequence analysis shows that each subunit also contains a welldefined PAS-like domain, and a predicted helical region. The N-termini of the aand b-subunits are homologous to the H-NOX (Heme-Nitric o...
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micrornas participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of micrornas in the pathogenesis of asthma. a review of the english medical literatures was conducted by searching pubmed for studies concerning asthma and micrornas. the results of the present study indicate that micrornas play important roles in regulating asthma immune res...
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he protein that does everything, 14–3-3, has now been shown to direct traffic. Ita O'Kelly, Steve Goldstein, and colleagues (Yale University, New Haven, CT) find that 14–3-3 can displace -COP from various proteins, thus freeing them from retention in the ER and leading to surface expression. Goldstein set out to find proteins interacting with the COOH terminus of a K ϩ leak channel, KCNK3, and...
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Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response to oxidative stress, cells activate expression of a number of genes, including those required for the detoxification of reactive molecules as well as for the repair and maintenance of cellular homeostasis. In many ...
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Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV) exposures, gamma-radiation and other environmental carcinogen...
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ژورنال
عنوان ژورنال: BMC Pharmacology and Toxicology
سال: 2015
ISSN: 2050-6511
DOI: 10.1186/2050-6511-16-s1-a26